Authors: Wei Zhang,1 Ibrahim Oraiqat,2 Hao Lei,3 Paul L. Carson,1,4 Issam EI Naqa,2 and Xueding Wang1,4 ABSTRACT Objective. The goal is to increase the precision of radiation delivery during radiotherapy by tracking the movements of the tumor and other surrounding normal tissues due to respiratory and other body motions. Introduction. This work presents the recent advancement of X-ray-induced radiation acoustic imaging (xRAI) […]
Tag: in vivo
GOLD NANOPARTICLES CONJUGATED WITH DNA APTAMER FOR PHOTOACOUSTIC DETECTION OF HUMAN MATRIX METALLOPROTEINASE-9
Authors: Jinhwan Kim, Anthony M Yu, Kelsey P. Kubelick, Stanislav Y. Emelianov ABSTRACT Matrix metalloproteinase-9 (MMP-9) plays major roles in extracellular matrix (ECM) remodeling and membrane protein cleavage, suggesting a high correlation with cancer cell invasion and tumor metastasis. Here, we present a contrast agent based on a DNA aptamer that can selectively target human […]
PHOTOACOUSTIC TOMOGRAPHY TO ASSESSACUTE VASOACTIVITY OF SYSTEMIC VASCULATURE
Author(s): Huda, Kristieª; Lawrence, Dylanª; Lindsey, Sarah; Bayer, Carolynª* ABSTRACT Vasoactivity is an important physiological indicator of cardiovascular health which is frequently measured using ex vivo vessels to determine functional mechanisms and evaluate pharmacological responses. Currently, there are no imaging methods available to assess vasoactivity in multiple vascular beds of living animals noninvasively. In this […]
DEEP LEARNING ENABLED REAL-TIME PHOTOACOUSTIC TOMOGRAPHY SYSTEM VIA SINGLE DATA ACQUISITION CHANNEL
Authors: Hengrong Lan, Daohuai Jiang, Feng Gao, Fei Gao ABSTRACT Photoacoustic computed tomography (PACT) combines the optical contrast of optical imaging and the penetrability of sonography. In this work, we develop a novel PACT system to provide real-time imaging, which is achieved by a 120-elements ultrasound array only using a single data acquisition (DAQ) channel. […]
PHOTOACOUSTIC IMAGING FOR IN VIVO QUANTIFICATION OF ALCOHOL-INDUCED STRUCTURAL AND FUNCTIONAL CHANGES IN CEREBRAL VASCULATURE IN HIGH ALCOHOL-PREFERRING MICE (HAP)
Authors: Augustine Meombe Mbolle, Hao Yang, Huabei Jiang* ABSTRACT Alcohol-induced structural and functional changes were studied in vivo by photoacoustic tomography (PAT) of the cerebrovascular system in selectively bred alcohol-preferring mice. High (HAP) and low (LAP) alcohol-preferring mice are replicate lines of mice selectively bred to prefer 10% (v/v) ethanol to water and water to […]
SIZE-ADJUSTABLE RING-SHAPE PHOTOACOUSTIC TOMOGRAPHY IMAGER IN VIVO
Author(s): Daohuai Jiang1,2,3, Yifei Xu1, Hengrong Lan1,2,3, Yuting Shen1, Yifan Zhang1,Feng Gao1, Li Liu4*, Fei Gao1,5* ABSTRACT Photoacoustic tomography (PAT) has become a novel biomedical imaging modality for scientific research and clinical diagnosis. It combines the advantages of spectroscopic optical absorption contrast and acoustic resolution with deep penetration. In this article, an imaging size-adjustable PAT […]
REAL-TIME, VOLUMETRIC IMAGING OF RADIATION DOSE DELIVERY DEEP INTO THE LIVER DURING CANCER TREATMENT
Authors: Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kai-Wei Chang, Scott Hadley, Noora Ba Sunbul, Martha M. Matuszak, Christopher J. Tichacek, Eduardo G. Moros, Paul L. Carson, Kyle C. Cuneo, Xueding Wang, & Issam El Naqa ABSTRACT Ionizing radiation acoustic imaging (iRAI) allows online monitoring of radiation’s interactions with tissues during radiation therapy, providing real-time, adaptive […]
CHARACTERIZING A PHOTOACOUSTIC AND FLUORESCENCE IMAGING PLATFORM FOR PRECLINICAL MURINE LONGITUDINAL STUDIES
Author(s): Weylan R. Thompson, Hans-Peter F. Brecht, Vassili Ivanov, Anthony M. Yu, Diego S. Dumani, Dylan J. Lawrence, Stanislav Y. Emelianov, Sergey A. Ermilov ABSTRACT SIGNIFICANCE To effectively study preclinical animal models, medical imaging technology must be developed with a high enough resolution and sensitivity to perform anatomical, functional, and molecular assessments. Photoacoustic (PA) tomography […]
DEEP LEARNING ENABLED REAL-TIME PHOTOACOUSTIC TOMOGRAPHY SYSTEM VIA SINGLE DATA ACQUISITION CHANNEL
Author(s): Hengrong Lan, Daohuai Jiang, Feng Gao, Fei Gao ABSTRACT Photoacoustic computed tomography (PACT) combines the optical contrast of optical imaging and the penetrability of sonography. In this work, we develop a novel PACT system to provide real-time imaging, which is achieved by a 120-elements ultrasound array only using a single data acquisition (DAQ) channel. To reduce the channel number of DAQ, we superimpose 30 nearby […]
Y-NET: HYBRID DEEP LEARNING IMAGE RECONSTRUCTION FOR PHOTOACOUSTIC TOMOGRAPHY IN VIVO
Author(s): Hengrong Lan, Daohuai Jiang, Changchun Yang, Feng Gao, Fei Gao ABSTRACT Conventional reconstruction algorithms (e.g., delay-and-sum) used in photoacoustic imaging (PAI) provide a fast solution while many artifacts remain, especially for limited-view with ill-posed problem. In this paper, we propose a new convolutional neural network (CNN) framework Y-Net: a CNN architecture to reconstruct the initial PA pressure distribution by optimizing both raw data and beamformed images […]