Recent Posts

Multimodal Imaging

What is Multimodal Imaging?

Multimodal Imaging is the combination of two or more imaging modalities that leverage the strengths of each modality. Multimodal imaging enhances the anatomical, functional, and molecular information obtained in a single imaging session.

PhotoSound’s Tritom imaging system utilizes the same short pulse duration OPO light source to generate the photoacoustic as well as the fluorescence image which allows the fast generation of tomographic images in both photoacoustic and fluorescence modality.
MolceulUS allows co-registered photoacoustic and ultrasonic image acquisition from a single transducer. The system is capable of generating ultrasound images while sequentially capturing the low SNL broadband photoacoustic images.

multimodal imaging
Multimodal Images by the TriTom
moleculus
Multimodal Images by the MoleculUS

PhotoSound Product Used

TriTom

Preclinical Small Animal Imaging Platform Providing Co-Registered 3D Maps of Photoacoustic Response and Fluorescence

A preclinical small animal imaging platform combining multi-angle photoacoustic and fluorescence projections into co-registered 3D maps

Co-registered photoacoustic and fluorescent imaging of a switchable nanoprobe based on J-aggregates of indocyanine green

Legion AMP

Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system

MoleculUS

A combined ultrasound and photoacoustic imaging platform for clinical research applications

Hybrid Photoacoustic Ultrasound Imaging System for Cold-Induced Vasoconstriction and Vasodilation Monitoring

Cardiac Imaging

PhotoSounds OEM Line of products is an ideal starting point for the development of custom systems where the parallel acquisition of multiple channels is required. All our ADCs are streaming and allow the continuous acquisition of data straight to the receiving computer for processing or storage.

PhotoSound’s ADCs are feature-rich, they have multiple electronic and optical trigger inputs as well as programmable outputs that allow the timing control of additional devices. It is possible to combine multiple ADCs in parallel. Simultaneous acquisition of 4096 channels has been realized routinely.

What is Cardiac Imaging?

Cardiac Imaging is the use of medical imaging techniques to study the structure and function of the cardiovascular system, focusing on the heart. Photoacoustic tomography has been used to image the heart, blood vessels, and other parts of the cardiovascular system.

Heart
Cardiovascular Imaging

PhotoSound Product Used

Legion ADC

Non-invasive photoacoustic computed tomography of rat heart anatomy and function

Tissue Engineering & Regeneration

What is Tissue Engineering & Regeneration?

Tissue engineering is the process of creating new tissues and organs to replace damaged or diseased tissues. Photoacoustic tomography can be used to evaluate tissue regeneration and vascularization.

deep tissue engineering
High energy 1064 nm excitation of mouse thorax and upper abdomen.

PhotoSound Product Used

TriTom

Photoacoustic Image-Guided Delivery of Plasmonic-Nanoparticle-Labeled Mesenchymal Stem Cells to the Spinal Cord

MoleculUS

A Combined Ultrasound and Photoacoustic Imaging Platform for Clinical Research Applications

Disease Monitoring

PhotoSounds OEM Line of products is an ideal starting point for the development of custom systems where the parallel acquisition of multiple channels is required. All our ADCs are streaming and allow the continuous acquisition of data straight to the receiving computer for processing or storage.

PhotoSound’s ADCs are feature-rich, they have multiple electronic and optical trigger inputs as well as programmable outputs that allow the timing control of additional devices. It is possible to combine multiple ADCs in parallel. Simultaneous acquisition of 4096 channels has been realized routinely.

How does PhotoSound equipment aid with disease monitoring?

PhotoSound imaging equipment has been developed to aid in the research of disease progression, using their abilities to generate highly sensitive and high-resolution anatomical images whether due to structural changes from Alcohol Use Disorder, monitoring vasoconstriction during hypothermia, or imaging neovascular formation in cancer, including liver and heart disease.

High Alcohol Preferring Mice
Estimation and comparison of selected blood vessels between HAP mice and LAP mice. 

PhotoSound Product Used

Legion ADC

Photoacoustic imaging for in vivo quantification of alcohol-induced structural and functional changes in cerebral vasculature in high alcohol-preferring mice (HAP)

Neuroimaging

Anatomical Imaging

What is anatomical imaging?

Anatomical imaging is used to visualize the structure and organization of tissues and organs within the body. Photoacoustic tomography generates high-resolution images of blood-rich tissues without the need for exogenous contrast agents.

PhotoSound Product Used

TriTom

Dual-Scan Photoacoustic Tomography for the Imaging of Vascular Structure on Foot

Photoacoustic tomography to assess acute vasoactivity of systemic vasculature
Breakthrough instruments and products PhotoSonus M+ laser for photoacoustic imaging

MoleculUS

Hybrid Photoacoustic Ultrasound Imaging System for Cold-induced Vasoconstriction and Vasodilation Monitoring

A combined ultrasound and photoacoustic imaging platform for clinical research applications

Legion ADC

High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

Evaluation of ultrasound sensors for transcranial photoacoustic sensing and imaging

Whole-Body Human Ultrasound Tomography
Automatic force-controlled 3D photoacoustic system for human peripheral vascular imaging

Radiation-Induced Acoustic Signal Denoising using a Supervised Deep Learning Framework for Imaging and Therapy Monitoring

Y-Net: Hybrid deep learning image reconstruction for photoacoustic tomography in vivo

Deep learning enabled real-time photoacoustic tomography system via single data acquisition channel

Improving photoacoustic imaging in low signal-to-noise ratio by using spatial and polarity coherence

Non-Invasive 3D Photoacoustic Tomography of Angiographic Anatomy and Hemodynamics of Fatty Livers in Rats
Size-adjustable ring-shape photoacoustic tomography imager in vivo
Photoacoustic Imaging for in vivo quantification of alcohol-induced structural and functional changes in cerebral vasculature in high alcohol-preferring mice (HAP)
Real-time photoacoustic data acquisition with a thousand parallel channels at hundreds frames per second
Massive parallel ultrasound and photoacoustic PC-based system
Monitoring Neonatal Brain Hemorrhage Progression by Photoacoustic Tomography

Legion AMP

Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy

Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment
Improving photoacoustic imaging in low signal-to-noise ratio by using spatial and polarity coherence

Automatic force-controlled 3D photoacoustic system for human peripheral vascular imaging

Non-invasive photoacoustic computed tomography of rat heart anatomy and function

Cancer Imaging

What is Cancer Imaging?

Cancer imaging: In applications related to cancer, photoacoustic tomography has been used to noninvasively monitor tumor size, evaluate tumor metastasis, and detect the response to novel cancer therapies.

breast cancer illustration
Early detection of breast cancer matters

PhotoSound Product Used

TriTom

Water-Soluble Fe(II) Complexes for Theranostic Application: Synthesis, Photoacoustic Imaging, and Photothermal Conversion
Co-registered photoacoustic and fluorescent imaging of a switchable nanoprobe based on J-aggregates of indocyanine green
Gold nanoparticles conjugated with DNA aptamer for photoacoustic detection of human matrix metalloproteinase-9

Legion ADC

High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

Whole-Body Human Ultrasound Tomography
Radiation-Induced Acoustic Signal Denoising Using a Supervised Deep Learning Framework for Imaging and Therapy Monitoring

Y-Net: Hybrid Deep Learning Image Reconstruction for Photoacoustic Tomography In Vivo

Deep Learning Enabled Real-Time Photoacoustic Tomography System Via Single Data Acquisition Channel

Non-Invasive 3D Photoacoustic Tomography of Angiographic Anatomy and Hemodynamics of Fatty Livers in Rats

Size-Adjustable Ring-Shape Photoacoustic Tomography Imager In Vivo

Massive Parallel Ultrasound and Photoacoustic PC-Based System

Legion AMP

Dual-Modality X-Ray-Induced Radiation Acoustic and Ultrasound Imaging for Real-Time Monitoring of Radiotherapy

Real-Time, Volumetric Imaging of Radiation Dose Delivery Deep into the Liver During Cancer Treatment
Automatic Force-Controlled 3D Photoacoustic System for Human Peripheral Vascular Imaging

Contrast Agent Development

Developmental Biology

What is Developmental Biology?

Photoacoustic tomography can be used to visualize and monitor the early stages of embryonic development and detect abnormalities that can affect maternal and fetal outcomes.

petri dish
Microbiology, Discovery and Exploration

PhotoSound Product Used

TriTom

Functional photoacoustic imaging for placental monitoring: A mini review

Legion ADC

Monitoring neonatal brain hemorrhage progression by photoacoustic tomography