02 August 2023 Author(s): Ruochong Zhang, Xiuting Li, Ghayathri Balasundaram, Baocheng Li, Yi Qi, Anindita Santosa, Tze Chin Tan, Malini Olivo, Renzhe Bi ABSTRACT Lewis hunting reaction refers to the alternating cold-induced vasoconstriction and dilation in extremities, whose underlying mechanism is complex. While numerous studies reported this intriguing phenomenon by measuring cutaneous temperature fluctuation under cold exposure, few of them tracked peripheral vascular […]
Category: Publication
A 3D IMAGING SYSTEM INTEGRATING PHOTOACOUSTIC AND FLUORESCENCE ORTHOGONAL PROJECTIONS FOR ANATOMICAL, FUNCTIONAL, AND MOLECULAR ASSESSMENT OF RODENT MODELS
16 March 2018 Authors: Hans P. Brecht, Vassili Ivanov, Diego S. Dumani, Stanislav Y. Emelianov, Mark A. Anastasio, Sergey A. Ermilov ABSTRACT We have developed a preclinical 3D imaging instrument integrating photoacoustic tomography and fluorescence (PAFT) addressing known deficiencies in sensitivity and spatial resolution of the individual imaging components. PAFT is designed for simultaneous acquisition of photoacoustic and fluorescence orthogonal […]
REAL-TIME PHOTOACOUSTIC DATA ACQUISITION WITH A THOUSAND PARALLEL CHANNELS AT HUNDREDS FRAMES PER SECOND
Authors: Vassili Ivanov, Hans Peter Brecht, Sergey A. Ermilov AFFILIATIONS PhotoSound Technologies, Inc. (United States) ABSTRACT Large number of simultaneously acquired spatially distinct pressure signals is required to improve quality of real-time photoacoustic and x-ray acoustic biomedical images [1]. In the past this approach was limited by availability of commercial multi-channel analog-to-digital converter (ADC) systems […]
CO-REGISTERED PHOTOACOUSTIC AND FLUORESCENT IMAGING OF A SWITCHABLE NANOPROBE BASED ON J-AGGREGATES OF INDOCYANINE GREEN
Authors: Diego S. Dumani, Hans-Peter Brecht, Vassili Ivanov, Ryan Deschner, Justin T. Harris, Kimberly A. Homan, Jason R. Cook, Stanislav Y. Emelianov, Sergey A. Ermilov ABSTRACT We introduce a preclinical imaging platform – a 3D photoacoustic/fluorescence tomography (PAFT) instrument augmented with an environmentally responsive dual-contrast biocompatible nanoprobe. The PAFT instrument was designed for simultaneous acquisition […]
MASSIVE PARALLEL ULTRASOUND AND PHOTOACOUSTIC PC-BASED SYSTEM
Authors: Weylan Thompson, Hans Peter Brecht, Sergey Ermilov, Vassili Ivanov ABSTRACT PhotoSound Technologies specializes in the development of electronics solutions for massive parallel data acquisition applicable to the fields of photoacoustics (PA), X-ray acoustics, including 3D dosimetry, and ultrasound. PhotoSound’s Legion ADC256 R1.1, released in 2018, is a 256-channel 12-bit ADC with a sampling rate […]
COMMERCIAL SMALL ANIMAL IMAGING COULD AID DISEASE DETECTION
Authors: Mark Little ABSTRACT The development of anticancer metastatic therapies for human clinical trials requires meticulous evaluation of efficacy and optimization of small animal test models in preclinical experimentation. Critical information on morphology and the molecular microenvironment of tumors is currently obtained and monitored using noninvasive, in vivo imaging methods. Detection of individual, small tumors […]
A PRECLINICAL SMALL ANIMAL IMAGING PLATFORM COMBINING MULTI-ANGLE PHOTOACOUSTIC AND FLUORESCENCE PROJECTIONS INTO CO-REGISTERED 3D MAPS
Authors: Weylan Thompson, Anthony Yu, Diego S. Dumani, Jason Cook, Mark A. Anastasio, Stanislav Y. Emelianov, Sergey A. Ermilov ABSTRACT We present the results on development of the 3D imaging platform combining photoacoustic tomography and fluorescence (PAFT) for preclinical and biological research. This combined multimodal imaging instrument addresses known deficiencies in sensitivity, spatial resolution, and […]
PHOTOACOUSTIC IMAGE-GUIDED DELIVERY OF PLASMONIC-NANOPARTICLE-LABELED MESENCHYMAL STEM CELLS TO THE SPINAL CORD
Authors: Eleanor M. Donnelly, Kelsey P. Kubelick, Diego S. Dumani, and Stanislav Y. Emelianov ABSTRACT Regenerative therapies using stem cells have great potential for treating neurodegenerative diseases and traumatic injuries in the spinal cord. In spite of significant research efforts, many therapies fail at the clinical phase. As stem cell technologies advance toward clinical use, […]
TECHNICAL CONSIDERATIONS IN THE VERASONICS RESEARCH ULTRASOUND PLATFORM FOR DEVELOPING A PHOTOACOUSTIC IMAGING SYSTEM
Authors: Karl Kratkiewicz1,4,Rayyan Manwar2,4, Yang Zhou, Moein Mozaffarzadeh3, Kamran Avanaki2 ABSTRACT Photoacoustic imaging (PAI) is an emerging functional and molecular imaging technology that has attracted much attention in the past decade. Recently, many researchers have used the vantage system from Verasonics for simultaneous ultrasound (US) and photoacoustic (PA) imaging. This was the motivation to write […]
PRECLINICAL SMALL ANIMAL IMAGING PLATFORM PROVIDING CO-REGISTERED 3D MAPS OF PHOTOACOUSTIC RESPONSE AND FLUORESCENCE
Authors: Diego S. Dumani1,2, Anthony Yu1,2, Weylan Thompson3, Hans-Peter Brecht3, Vassili Ivanov3, Mark A. Anastasio4, Jason Cook5, Sergey A. Ermilov3, Stanislav Y. Emelianov1,2 ABSTRACT We report on the development of a preclinical 3D imaging platform integrating photoacoustic tomography and fluorescence (PAFT). The proposed multimodal imaging concept addresses known deficiencies in sensitivity, anatomical registration, and spatial […]