Authors: Weiran Pang, Bowen Zhu, Honghui Li, Yingying Zhou, Chi Man Woo, Xiazi Huang, Tianting Zhong, Hsuan Lo, Laiyou Wang, Puxiang Lai, Liming Nie ABSTRACT Brain voltage plays a crucial role in indicating internal functions or diseases, and optical voltage imaging has gained intensive attention in recent years. Despite encouraging progress, current implementations encounter limitations […]
Category: Publication
4D IN VIVO DOSIMETRY FOR A FLASH ELECTRON BEAM USING RADIATION-INDUCED ACOUSTIC IMAGING
Authors: Kristina Bjegovic, Leshan Sun, Prabodh Pandey, Veljko Grilj, Paola Ballesteros-Zebadua, Ryan Paisley, Gilberto Gonzalez, Siqi Wang, Marie Catherine Vozenin, Charles L Limoli and Shawn (Liangzhong) Xiang ABSTRACT Objective. The primary goal of this research is to demonstrate the feasibility of radiation-induced acoustic imaging (RAI) as a volumetric dosimetry tool for ultra-high dose rate FLASH […]
TOWARD REAL-TIME, VOLUMETRIC DOSIMETRY FOR FLASH-CAPABLE CLINICAL SYNCHROCYCLOTRONS USING PROTOACOUSTIC IMAGING
Authors: Siqi Wang, Gilberto Gonzalez, Daniel Rocky Owen, Leshan Sun, Yan Liu, Townsend Zwart, Yong Chen, Liangzhong Xiang ABSTRACT BackgroundRadiation delivery with ultra-high dose rate (FLASH) radiotherapy (RT) holds promise for improving treatment outcomes and reducing side effects but poses challenges in radiation delivery accuracy due to its ultra-high dose rates. This necessitates the development […]
REAL-TIME TRACKING OF THE BRAGG PEAK DURING PROTON THERAPY VIA 3D PROTOACOUSTIC IMAGING IN A CLINICAL SCENARIO
Authors: Siqi Wang, Gilberto Gonzalez, Leshan Sun, Yifei Xu, Prabodh Pandey, Yong Chen & Shawn (Liangzhong) Xiang ABSTRACT Proton radiotherapy favored over X-ray photon therapy due to its reduced radiation exposure to surrounding healthy tissues, is highly dependent on the accurate positioning of the Bragg peak. Existing methods like PET and prompt gamma imaging to […]
Multifunctional PtCuTe Nanosheets with Strong ROS Scavenging and ROS-Independent Antibacterial Properties Promote Diabetic Wound Healing
Author(s): Yaru Guo, Shuai Ding, Changshuai Shang, Chenguang Zhang, Menggang Li, Qinghua Zhang, Lin Gu, Boon Chin Heng, Shihan Zhang, Feng Mei, Ying Huang, Xuehui Zhang, Mingming Xu, Jiuhui Jiang, Shaojun Guo, Xuliang Deng, Lili Chen Abstract Nanozymes, as one of the most efficient reactive oxygen species (ROS)-scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving the catalytic efficiency of Pt-based nanozymes (e.g., PtCu, […]
Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy
Author(s): Iaroslav B. Belyaev, Ivan V. Zelepukin, Polina A. Kotelnikova, Gleb V. Tikhonowski, Anton A. Popov, Alina Yu. Kapitannikova, Jugal Barman, Alexey N. Kopylov, Daniil N. Bratashov, Ekaterina S. Prikhozhdenko, Andrei V. Kabashin, Sergey M. Deyev, Andrei V. Zvyagin Abstract Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical […]
The development of ionizing radiation acoustic imaging (iRAI) for mapping the dose deep in the patient body during radiation therapy
Author(s): Wei Zhang, Dale Litzenberg, Yaocai Huang, Kai-Wei Chang, Ibrahim Oraiqat, Scott Hadley, Eduardo G. Moros, Man Zhang, Paul L. Carson, Kyle C. Cuneo, Issam EI Naqa, Xueding Wang Abstract Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is the development of iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition […]
Toward in vivo dosimetry in external beam radiotherapy using x-ray acoustic computed tomography: A soft-tissue phantom study validation
Author(s): Hao Lei, Wei Zhang, Ibrahim Oraiqat, Zhipeng Liu, Jun Ni, Xueding Wang, Issam El Naqa Abstract Purpose: To study, using phantoms made from biological tissues, the feasibility and practical challenges of monitoring the position of the radiation beam and the deposited dose by x-ray acoustic computed tomography (XACT) during external beam radiotherapy delivery. Material and methods: A prototype XACT system […]
GPU-Accelerated 3D Volumetric X-Ray-Induced Acoustic Computed Tomography
Author(s): Donghyun Lee, Eun-Yeong Park, Seongwook Choi, Hyeongsub Kim, Jung-joon Min, Changho Lee, and Chulhong Kim ABSTRACT X-ray acoustic imaging is a hybrid biomedical imaging technique that can acoustically monitor X-ray absorption distribution in biological tissues through the X-ray induced acoustic effect. In this study, we developed a 3D volumetric X-ray-induced acoustic computed tomography (XACT) […]
Spatiotemporal Image Reconstruction to Enable High-Frame-Rate Dynamic Photoacoustic Tomography with Rotating-Gantry Volumetric Imagers
Author(s): Refik Mert Cam, Chao Wang, Weylan Thompson, Sergey A. Ermilov, Mark A. Anastasio, Umberto Villa ABSTRACT Significance Dynamic photoacoustic computed tomography (PACT) is a valuable imaging technique for monitoring physiological processes. However, current dynamic PACT imaging techniques are often limited to two-dimensional spatial imaging. Although volumetric PACT imagers are commercially available, these systems typically employ a rotating measurement gantry […]